Systems, apparatuses, and methods for tracking the status and use of packaged goods are provided. The systems of the invention coordinate various stakeholders, hardware devices, computer software systems, standards, methods, procedures, practices and their interconnection in ways that lead to greater efficiency, safety, and efficacy, along with potentially lower cost, and less waste in the delivery of packaged goods and their use. In one aspect a Medication Management System (“MMS”) that tracks the status of packaged medications and patient compliance is also provided.