The present invention provides devices for screening the skin of an individual in real time using a region-fusion based segmentation with narrow band graph partitioning algorithm to analyze and classify a region of interest of the skin as benign or malignant. Also, provided is a method for screening the skin of an individual using the devices described herein. In addition the present invention provides a digital processor-implemented system for classifying a region of interest on the skin and a processor readable medium having processor-executable instructions to perform skin cancer detection.