A jaw release mechanism for locking pliers which utilize an over-center toggle locking mechanism and wherein the normally stationary upper jaw of the pliers is pivotally fastened to the main body of the pliers. This normally stationary upper jaw is releaseably retained in a normally stationary position relative to the main body of the pliers by a thumb actuated trigger release mechanism whereby the locked pliers may be safely released with the same hand which grasps and manipulates the pliers.