Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Margaret M. DeAngelis0
Date of Patent
July 31, 2012
Patent Application Number
13115912
Date Filed
May 25, 2011
Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention provides methods and compositions for determining whether a subject is at risk of developing age-related macular degeneration, for example, the wet or neovascular form of age-related macular degeneration. The method involves determining whether the subject has a protective variant and/or a risk variant at a polymorphic site in the HTRA1 gene. In addition, the invention provides a method of treating or slowing the progression of age-related macular degeneration by reducing the expression of the HTRA1 gene, or reducing the biological activity of the HTRA1 gene product.
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