A protective frame for portable electronic devices consists of a main frame and a cover. The main frame is provided with a window, a recessed entry formed in a lower side, at least one positioning projection located at the recessed entry and separated by a groove, and a sliding groove cut in the inner walls of other three sides. The cover is laid on the main frame, having an opening, an engaging projection protruding outward around three sides to slide in and engage with the sliding groove, at least one recessed groove cut in the inner wall to correspond to the positioning projections of the main frame, a positioning projection formed at the end of each recessed groove, and an interlocking groove bored next to the outer edge of each positioning projection. Hence, a portable electronic device can be wrapped up by the protective frame to prevent it from damaged.