A multi-angle hand tool for a handle includes a shank including a body, and a compartment defined in the body. An operating device includes a connecting end having an engaging portion defined thereon. A guide is mounted in the compartment and includes an embedding portion defined thereon. A connecting device is disposed and interconnected between the operating device and the guide. The multi-angle hand tool has a plurality of operation modes, and, in each operation mode, the operating device is prevented from moving and pivoting with respect to the shank by engaging the engaging portion with the embedding portion. Furthermore, a longitudinal length of the operating device is perpendicular to, angled non-perpendicularly to, or aligned with the longitudinal length of the body of the shank selectively for different operation modes.