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US Patent 8349326 Methods and systems for multi-antibody therapies

Patent 8349326 was granted and assigned to Tufts University School of Medicine on January, 2013 by the United States Patent and Trademark Office.

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Patent
Patent

Patent attributes

Current Assignee
Tufts University School of Medicine
Tufts University School of Medicine
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8349326
Date of Patent
January 8, 2013
Patent Application Number
12889511
Date Filed
September 24, 2010
Patent Citations Received
‌
US Patent 12084519 Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein
0
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US Patent 12065486 VHH based binding antibodies for anthrax and botulinum toxins and methods of making and using therefor
0
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US Patent 12077576 VHH polypeptides that bind to
0
Patent Primary Examiner
‌
Phuong Huynh
Patent abstract

The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each of the binding agents has one or more monomers that have a binding region that is specific to a portion of a disease agent and one or more copies of a tag. The binding agents can be specific to one or more portions of the same or different disease agents. The tag is the same for each of the binding agents. The methods include administering an anti-tag antibody, wherein the anti-tag antibody has an anti-tag region that is specific to the tag, and can have an immunoglobulin (e.g., IgA, IgD, IgE, IgG, and IgM). Disease agents include bacteria, bacterial proteins, viruses, viral proteins, cancer cells, and proteins or toxins produced therefrom or from other sources such as snakes, insects, plants, etc. In particular, the present invention includes methods and systems for binding agents having one or more monomers that are specific to neurotoxins that cause botulism.

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