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US Patent 8362233 Stabilized immune modulatory RNA (SIMRA) compounds

Patent 8362233 was granted and assigned to Idera Pharmaceuticals on January, 2013 by the United States Patent and Trademark Office.

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Current Assignee
Idera Pharmaceuticals
Idera Pharmaceuticals
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
83622330
Patent Inventor Names
Sudhir Agrawal0
Daqing Wang0
Ekambar R. Kandimalla0
Lakshmi Bhagat0
Tao Lan0
Date of Patent
January 29, 2013
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Patent Application Number
133597140
Date Filed
January 27, 2012
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Patent Citations Received
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US Patent 11767531 Defined multi-conjugates oligonucleotides
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US Patent 11859184 Multi-conjugate of siRNA and preparing method thereof
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Patent Primary Examiner
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Kimberly Chong
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Patent abstract

The invention relates to the therapeutic use of novel stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides novel RNA-based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.

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