Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michael Fung0
Cecily R. Y. Sun0
Meisheng Lu0
William N. C. Sun0
Date of Patent
February 12, 2013
0Patent Application Number
134823280
Date Filed
May 29, 2012
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention relates to inhibitors that bind to C5 and C5a, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of such an inhibitor molecule is the monoclonal antibody designated MAb137-26, which binds to a shared epitope of human C5 and C5a. These inhibitors may be used to inhibit the activity of C5a in treating diseases and conditions mediated by excessive or uncontrolled production of C5a. The inhibitor molecules are also useful for diagnostic detection of the presence/absence or amount of C5 or C5a.
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