A folding knife in exemplary embodimentsTong comprises a handle portion, a blade, a locking cross-bolt, and a motion limiting member coupled to the handle. When the blade is in the closed position, the motion limiting member is in a first position that prevents the cross-bolt from moving to its locked position. When pivoting the blade to the open position, the motion limiting member moves to a second position that does not prevent the cross-bolt from moving to its locked position. A biased safety mechanism can also be used to block the cross-bolt from moving to an unlocked position.