US Patent 8394947 Positionally modified siRNA constructs
Patent 8394947 was granted and assigned to Ionis Pharmaceuticals on March, 2013 by the United States Patent and Trademark Office.
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Patent abstract
The present invention provides oligomeric compounds having sufficient complementarity to hybridize to a nucleic acid target and methods for their use in modulating gene expression. In one embodiment the oligomeric compounds comprise double stranded constructs wherein one of the strands capable of hybridizing to a nucleic acid target, and has a plurality of modified ribofuranosyl nucleosides at defined locations. The presence of modifications at such defined positions greatly enhances the properties of the corresponding compositions.
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Patent Inventor Names
Balkrishen Bhat0
Charles Allerson0
Eric E. Swayze0
Prasad Dande0
Richard H. Griffey0
Thazha P. Prakash0
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US Patent 08394947 Positionally modified siRNA constructs US Patent 8394947 Positionally modified siRNA constructs
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Patent Number
083949470
Patent Number
83949470
Edits on 27 Sep, 2022
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Is a
Current Assignee
Patent Jurisdiction
Patent Number
083949470
Date of Patent
March 12, 2013
0Patent Application Number
115699390
Date Filed
March 3, 2004
0Patent Primary Examiner
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US Patent 08394947 Positionally modified siRNA constructs
Infobox
Is a
Current assignee
Patent jurisdiction
Patent number
08394947
Date of patent
March 12, 2013
Patent application number
11569939
Date Filed
March 3, 2004
Patent primary examiner
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