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US Patent 8404830 Method for generating aptamers with improved off-rates

Patent 8404830 was granted and assigned to SomaLogic, Inc. on March, 2013 by the United States Patent and Trademark Office.

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Patent abstract

The present disclosure is directed to the field of nucleic acid chemistry, specifically to 5-position modified uridines, as well as, oligonucleotides comprising said 5-position modified uridines. The present disclosure describes methods for producing aptamers comprising said 5-position modified uridines that are capable of binding to target molecules.

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