Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Loren Looger0
Peter Lee0
Scott Sternson0
Date of Patent
May 7, 2013
0Patent Application Number
125769340
Date Filed
October 9, 2009
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides novel chimeric receptors that have unique pharmacology. In particular, the chimeric receptors comprise a mutated ligand binding domain of the α7 nicotinic acetylcholine receptor fused to a transmembrane or channel domain from a ligand-gated ion channel protein. The mutations in the ligand binding domain confer selective binding of compounds. Methods of using the novel chimeric receptors of the invention as well as compounds that preferentially bind and activate the chimeric receptors are also disclosed.
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