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US Patent 8450460 Single-chain TNFSF fusion polypeptides

Patent 8450460 was granted and assigned to Apogenix on May, 2013 by the United States Patent and Trademark Office.

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Is a

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Patent attributes

Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Christian Gieffers0

Meinolf Thiemann0

Oliver Hill0

Date of Patent

May 28, 2013

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Patent Application Number

130551090

Date Filed

July 18, 2009

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Patent Citations Received

US Patent 12104172 Processes for generating TIL products enriched for tumor antigen-specific t-cells

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US Patent 11713446 Processes for generating TIL products enriched for tumor antigen-specific T-cells

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US Patent 11866688 Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy

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US Patent 11981921 TIL expansion processes using specific cytokine combinations and/or AKTi treatment

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US Patent 12024718 Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy

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US Patent 12071465 Methods of making and using extracellular domain-based chimeric proteins

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Patent Primary Examiner

Robert Landsman

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Patent abstract

The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.

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