A peristaltic pump assembly comprises a pump and a removable cassette. The pump includes a pumping mechanism portion having opposed inner and outer walls defining a slot opening therebetween, and further having a cassette mounting pin extending at least partially across the slot opening. The removable cassette includes a cylindrical hinge journal and a mounting channel merging in a radial direction with the hinge journal, whereby the cassette is mounted on the mounting pin by inserting the removable cassette into the slot opening between the inner and outer walls of the pumping mechanism portion in a radial direction of the mounting pin such that the mounting pin is passed through the mounting channel and received by the hinge journal. The mounting pin and hinge journal are configured to allow the removable cassette to rotate about the mounting pin into and out of an installed position.