Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Kallanthottathil G. Rajeev0
Venkitasamy Kesavan0
Muthiah Manoharan0
Date of Patent
June 25, 2013
0Patent Application Number
126048970
Date Filed
October 23, 2009
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides single-stranded and double-stranded oligonucleotides comprising at least one aralkyl ligand that improvise the pharmacokinetic properties of the oligonucleotide. The aralkyl ligands of the present invention include naproxen, ibuprofen, and derivatives thereof. The present invention also provides method for modulating gene expression using the modified oligonucleotide compounds and compositions comprising those modified oligonucleotides.
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