Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Andreas Ivens0
Oliver Zoechling0
Peter Turecek0
Stefan Haider0
Hanspeter Rottensteiner0
Juergen Siekmann0
Date of Patent
February 4, 2014
0Patent Application Number
131940380
Date Filed
July 29, 2011
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
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