US Patent 8674073 Immunoglobulin affinity ligand
Patent 8674073 was granted and assigned to ProteNova Co.,Ltd on March, 2014 by the United States Patent and Trademark Office.
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Provided is affinity chromatography carrier for an immunoglobulin that simultaneously has high immunoglobulin-binding capability and chemical stability and that can be produced at low cost. An immunoglobulin-binding protein in which an amino acid substitution for not only maximizing the number of lysine residues on the protein surface of helix 3 and its periphery but also minimizing the number of lysine residues present on the protein surfaces of helix 1 and helix 2 as immunoglobulin-binding regions and/or an amino acid substitution for eliminating an aspartic acid-proline sequence have (has) been carried out, or a multimer thereof, is used as an affinity ligand for an affinity chromatography carrier.
US Patent 08674073 Immunoglobulin affinity ligand US Patent 8674073 Immunoglobulin affinity ligand
US Patent 08674073 Immunoglobulin affinity ligand
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