Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Stephen Martin Courtney0
Vincent Jacob Kalish0
Andrew D. Cohen0
Frederick Arthur Brookfield0
John P. Toscano0
Lisa Marie Frost0
Date of Patent
March 18, 2014
0Patent Application Number
135313640
Date Filed
June 22, 2012
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
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