Systems, methods and articles of manufacture are disclosed for presenting image slices in a windowing environment based on multi-touch user input, the image slices generated by an imaging system. A series of image slices may be provided that represent a view of an object. A gesture may be defined based on at least a count of fingers represented in multi-touch user input. Further, the defined gesture may be associated with a corresponding action for manipulating an image slice. Multi-touch user input may be received. Upon determining that the received multi-touch user input includes the defined gesture, the corresponding action may be performed on an image slice of the series to generate a resultant image slice. The resultant image slice may be output via an output device.