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US Patent 8691730 Rationally designed, synthetic antibody libraries and uses therefor

Patent 8691730 was granted and assigned to Adimab, Llc on April, 2014 by the United States Patent and Trademark Office.

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Patent attributes

Current Assignee

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

Patent Inventor Names

Michael Feldhaus0

K. Dane Wittrup0

Maximiliano Vasquez0

Tillman U. Gerngross0

Date of Patent

April 8, 2014

Patent Application Number

12210072

Date Filed

September 12, 2008

Patent Citations Received

US Patent 11958909 Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use

0

US Patent 12071477 Anti-folate receptor alpha antibody conjugated with hemiasterlins

0

US Patent 11708413 Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates

0

Patent Primary Examiner

Christian Boesen

Patent abstract

The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.

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