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US Patent 8703714 Monomethylvaline compounds capable of conjugation to ligands

Patent 8703714 was granted and assigned to Seagen on April, 2014 by the United States Patent and Trademark Office.

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Patent abstract

Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.

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