Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Hwai Wen Chang0
Jay M. Short0
Gerhard Frey0
Date of Patent
April 29, 2014
Patent Application Number
13523509
Date Filed
June 14, 2012
Patent Citations Received
Patent Primary Examiner
Patent abstract
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.
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