US Patent 8710187 Modified binding proteins inhibiting the VEGF-A receptor interaction
Patent 8710187 was granted and assigned to Molecular Partners on April, 2014 by the United States Patent and Trademark Office.
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The present invention relates to binding proteins specific for Vascular Endothelial Growth Factor A (VEGF-A), in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx (wherein xxx denotes the amino acid length of the VEGF-A mature protein) binding to Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2). Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.
US Patent 08710187 Modified binding proteins inhibiting the VEGF-A receptor interaction US Patent 8710187 Modified binding proteins inhibiting the VEGF-A receptor interaction
US Patent 08710187 Modified binding proteins inhibiting the VEGF-A receptor interaction
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