Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Eric M. Ostertag0
John Stuart Crawford0
Date of Patent
May 13, 2014
0Patent Application Number
127662840
Date Filed
April 23, 2010
0Patent Citations Received
Patent Primary Examiner
Patent abstract
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.
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