The vehicle with wheelchair positioning mechanism includes an automotive vehicle that is modified to assist a disabled person to enter, operate and exit the vehicle. The modification includes a wheelchair lift adjacent the rear of the vehicle. An internal rail system extends from the rear of the vehicle to the front of the vehicle adjacent the vehicle's driving controls. A remotely controlled platform is rotatably mounted on a carriage for movement on the rail system. The platform is adapted to support a wheelchair thereon. The platform can be rotated 360° so that the wheelchair moves forward when entering and exiting the vehicle.