Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Niles A. Pierce0
Robert Dirks0
Date of Patent
February 24, 2015
Patent Application Number
13154989
Date Filed
June 7, 2011
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present application relates to the use of hybridization chain reaction (HCR) to form double stranded RNA polymers in the presence of a target, such as a nucleic acid associated with a disease or disorder. The RNA polymers are preferably able to activate the RNA-dependent kinase PKR. Activation of PKR via RNA-HCR can be used to treat a wide variety of diseases and disorders by specifically targeting diseased cells.
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