A reconfigurable applicator system for extrusive dispensing of a work material is provided. The system includes a body portion having an actuator coupled thereto. A frame portion coupled to the body portion defines a support structure for at least one cartridge unit containing the work material. A combination trigger handle portion is coupled to the body portion to be adjustable between angularly displaced first and second grip positions relative to the frame portion. The combination trigger handle portion includes at least first and second selectable triggers coupled to the actuator, which responds to each of the first and second triggers to actuate extrusive dispensing of the work material from the cartridge unit. The combination trigger handle portion in the first and second grip positions alternatively configures the system between overhand and underhand configurations.