Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Nupura S. Bhise0
Stephany Y. Tzeng0
Joel C. Sunshine0
Jordan J. Green0
Ron B. Shmueli0
Date of Patent
March 31, 2015
0Patent Application Number
133206210
Date Filed
May 17, 2010
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
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