A multi-level cache comprises a plurality of cache levels, each configured to cache I/O request data pertaining to I/O requests of a different respective type and/or granularity. A cache device manager may allocate cache storage space to each of the cache levels. Each cache level maintains respective cache metadata that associates I/O request data with respective cache address. The cache levels monitor I/O requests within a storage stack, apply selection criteria to identify cacheable I/O requests, and service cacheable I/O requests using the cache storage device.