Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
April 14, 2015
Patent Application Number
13513523
Date Filed
December 7, 2010
Patent Citations Received
Patent Primary Examiner
Patent abstract
Methods of enhancing the efficacy of antibody-directed cellular cytotoxicity (ADCC) for therapy directed to killing of tumor cells are disclosed. Cancer specific cell surface antigens are bound by monoclonal antibodies, thereby stimulating a cytotoxic T cell response characterized by an upregulation of cell surface expression of costimulatory molecules on the T cell. The ADCC response is augmented by the subsequent administration of a second antibody that is an agonist of the costimulatory molecule.
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