Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Narayanannair K. Jayaprakash0
Martin Maier0
Muthiah Manoharan0
Muthusamy Jayaraman0
Shigeo Matsuda0
Thomas A. Baillie0
Akin Akinc0
Kallanthottathil G. Rajeev0
Date of Patent
April 21, 2015
0Patent Application Number
131532000
Date Filed
June 3, 2011
0Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
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