US Patent 9012717 Human lambda light chain mice
Patent 9012717 was granted and assigned to Regeneron Pharmaceuticals on April, 2015 by the United States Patent and Trademark Office.
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Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided.
US Patent 09012717 Human lambda light chain mice US Patent 9012717 Human lambda light chain mice
US Patent 09012717 Human lambda light chain mice
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