A method of manufacturing a roll of bottom gusseted pouches serially connected in a top-to-bottom end orientation is provided. The method comprises unwinding a pouch webbing in a first flow direction, the pouch webbing defining front and back panels of a respective pouch; inserting a gusset webbing between the panels in a second flow direction; attaching the gusset webbing to the panels to form the bottom gusseted end of the pouch; inserting a closure mechanism between the panels in a third flow direction; attaching the closure mechanism to the panels to form the resealable top end of the pouch; sealing the side edges of the panels to complete the pouch; winding the completed pouch onto the roll; and repeating these steps to form the other bottom gusseted pouches in the roll. At least one of the pouch webbing and the gusset webbing is formed of a supported film.