Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Nobuhiro Nishiyama0
Yan Lee0
Kazunori Kataoka0
Takehiko Ishii0
Date of Patent
June 9, 2015
0Patent Application Number
132566050
Date Filed
September 17, 2009
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides a protein delivery means (e.g., a polyion complex) which allows efficient introduction into cells (particularly into the cytoplasm), is highly stable in serum, and is also widely applicable. The polyion complex of the present invention comprises a cationic polymer having a polycation moiety and a charge-conversional protein whose overall charge is converted from basic or neutral to acidic by a specific charge regulator.
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