Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
June 23, 2015
Patent Application Number
14265029
Date Filed
April 29, 2014
Patent Citations Received
Patent Primary Examiner
Patent abstract
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
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