Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Aaron K. Sato0
Austin L. Gurney0
Date of Patent
June 30, 2015
0Patent Application Number
127686500
Date Filed
April 27, 2010
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
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