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Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
August 18, 2015
0Patent Application Number
143182530
Date Filed
June 27, 2014
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to RSPO-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO proteins, such as antibodies that specifically bind RSPO1, RSPO2, and/or RSPO3 and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
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