In a method of calibrating a wireless communication device, a first sounding packet is transmitted from the wireless communication device to a calibration station. A first channel descriptor is generated based on the first sounding packet. A second sounding packet is transmitted from the calibration station to the wireless communication device. A second channel descriptor is generated based on the second sounding packet. The first channel descriptor and the second channel descriptor are obtained at a controller. Calibration coefficients indicative of one or both of phase imbalance and amplitude imbalance between a receive radio frequency (RF) chain and a transmit RF chain at the wireless communication device are generated based on the first and the second channel descriptors. The calibration coefficients are sent from the controller to the wireless communication device.