Systems and methods of vehicle climate control are provided. Specifically, a vehicle with climate control includes a number of sensors for sensing climate control information, such as human bodily conditions, e.g., temperature or heart rate, of the human occupants of the vehicle, a processing unit, and a climate control. The processing unit uses the sensed human bodily conditions data from the sensors to activate the climate control the adjust the climate conditions for the human occupants. In another aspect of the disclosure, stress level of the human operator of a vehicle can be detected by sensing the bodily conditions of the human operator, determining the stress level of the human operator based on the sensed bodily conditions, and displaying a warning if the stress level is over a certain limit.