Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
November 3, 2015
0Patent Application Number
105668980
Date Filed
August 6, 2004
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purification processes can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
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