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Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Date of Patent
November 10, 2015
0Patent Application Number
136517970
Date Filed
October 15, 2012
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention provides a natural killer cell, NK-92, modified to express an Fc receptor on the surface of the cell, such as CD16 (FcγRIII-A), or other Fcγ or Fc receptors. The modified NK-92 cell can be further modified to concurrently express an associated accessory signaling protein, such as FcεRI-γ,TCR-ζ, or to concurrently express interleukin-2 (IL-2) or other cytokines. Additional methods are disclosed for various assays, assessments, and therapeutic treatments with the modified NK-92 cells.
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