Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
December 1, 2015
0Patent Application Number
142702130
Date Filed
May 5, 2014
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
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