Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Sergey Kipriyanov0
Uwe Reusch0
Fabrice Le Gall0
Melvin Little0
Date of Patent
January 5, 2016
Patent Application Number
13739736
Date Filed
January 11, 2013
Patent Citations Received
Patent Primary Examiner
Patent abstract
Described are mono- and multivalent scFv-antibodies comprising the binding sites specific for the human T cell marker CD3. These antibodies are strongly immunosuppressive and do not cause a significant release of cytokines. Furthermore, polynucleotides encoding said antibodies are described as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Pharmaceutical compositions containing any of the above mentioned polynucleotides, antibodies or vectors are useful for immunotherapy, preferably against acute transplant rejections.
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