Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Tomoyuki Igawa0
Date of Patent
January 26, 2016
0Patent Application Number
119169790
Date Filed
June 9, 2006
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present inventor discovered stabilizing agents/stabilizing conditions for suppressing isomerization reactions of sc(Fv)2. It was also discovered that the above-mentioned isomerization reactions can be suppressed through use of freeze-dried formulations. As disclosed herein, by applying the discovered stabilizing agents/stabilizing conditions or the freeze-dried formulation, the isomerization reaction of an sc(Fv)2-type molecule from the bivalent scFv type to the single chain diabody type, and/or the isomerization reaction from a single chain diabody type to a bivalent scFv type can be suppressed in both directions or one direction.
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