Patent 9248199 was granted and assigned to Global Blood Therapeutics on February, 2016 by the United States Patent and Trademark Office.
Provide herein are 1:1 adducts of sickle hemoglobin (HbS) and a compound of formula (I), as defined herein, suitable as modulators of HbS, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.