Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jeremy Heidel0
Thomas Primiano0
Bey-Dih Chang0
Lonnie Bookbinder0
Date of Patent
March 1, 2016
0Patent Application Number
131139630
Date Filed
May 23, 2011
0Patent Citations Received
Patent Primary Examiner
Patent abstract
This invention describes a genetic system for targeting the EVI1 gene in mammalian cells. The EVI1 gene is an oncogenic transcription factor that, when expressed, accelerates cell division and inhibits death of cells. Nucleotide sequences that block the expression of EVI1 and drug delivery systems for them are described. These nucleotide sequences cause a block in cell growth and division and trigger death of mammalian cells, including lung and ovarian cancer cells.
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