Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
March 22, 2016
Patent Application Number
14164519
Date Filed
January 27, 2014
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates to a process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
