US Patent 9308582 Solution stable and chemically reactive metallic nanoparticles

Entity and methods for generating stable and chemically reactive metallic nanoparticles and stable metallic nano-probes. Polymeric coating molecules having at least one metal core binding motif and at least one chemically reactive functional moiety is stably bound to the surface of metallic nanoparticle via the metal core binding motif. A target specific probe molecule is covalently bound to the metallic nanoparticle via the chemically reactive functional moiety forming stable metallic nano-probe.