US Patent 9334489 CHO expression system
Patent 9334489 was granted and assigned to Sanofi on May, 2016 by the United States Patent and Trademark Office.
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The present invention is within the field of industrial protein production. The inventors have designed and constructed a new expression system comprising an expression vector coding for a glutamine synthetase of human or dog origin, and a CHO cell line. More specifically, the invention pertains to a combination of (i) a DNA vector suitable for production of a recombinant protein, wherein said vector comprises a sequence coding for a glutamine synthetase, and (ii) a Chinese Hamster Ovary (CHO) cell line, wherein said GS comprises a sequence at least 94.5% identical to the sequence of SEQ ID NO: 1 or to the sequence of SEQ ID NO: 2.
US Patent 09334489 CHO expression system US Patent 9334489 CHO expression system
US Patent 09334489 CHO expression system
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